LETTER TO JMG Germline E-cadherin mutations in familial lobular breast cancer
نویسندگان
چکیده
S Masciari, N Larsson, J Senz, N Boyd, P Kaurah, M J Kandel, L N Harris, H C Pinheiro, A Troussard, P Miron, N Tung, C Oliveira, L Collins, S Schnitt, J E Garber, D Huntsman . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
منابع مشابه
Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers
BACKGROUND Germline mutations in CDH1 are associated with hereditary diffuse gastric cancer; lobular breast cancer also occurs excessively in families with such condition. METHOD To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of CDH1 mutations in 318 women with lobu...
متن کاملLow Incidence of Germline and Somatic Alterations in the E-Cadherin Gene in Lobular Breast Carcinoma
Germline mutations of E-cadherin have been identified in families with gastric cancer. Moreover, E-cadherin has been shown to be inactivated in the majority of human invasive lobular breast cancers. E-cadherin is a tumor suppressor gene located in l6q22.1, a region which is frequently deleted in a variety of tumors. We therefore analysed 15 families with lobular breast cancer or breast and gast...
متن کاملGermline E-cadherin mutations in familial lobular breast cancer.
BACKGROUND The cell surface glycoprotein E-cadherin (CDH1) is a key regulator of adhesive properties in epithelial cells. Germline mutations in CDH1 are well established as the defects underlying hereditary diffuse gastric cancer (HDGC) syndrome, and an increased risk of lobular breast cancer (LBC) has been described in HDGC kindreds. However, germline CDH1 mutations have not been described in ...
متن کاملبررسی فراوانی بروز مارکرهای E-Cadherin , Dysadherinدر کارسینوم های پستان
Background and purpose: Breast carcinoma is the most common malignant tumor and the leading cause of death due to cancer among women. Previous studies have shown that increased expression of dysadherin promotes cancer metastasis and reduced expression of E-cadherin was also associated with progression of epithelial tumors. The aim of this study was concurrent assessment of E- cadherin and dysad...
متن کاملE-cadherin germline missense mutations in diffuse gastric cancer
Abstract Introduction Hereditary diffuse gastric cancer is an autosomal inherited syndrome associated with the E-cadherin germline mutations. Different types of CDH1 germline mutations have been reported; the missense alterations are rarely identified when compared with truncating mutations. The identification of missense mutation represents a clinical burden, since its pathogenicity is still u...
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تاریخ انتشار 2007